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Mounting evidence identifies the NLRP3 inflammasome as the central hub linking amyloid plaques, tau tangles, and cognitive decline — opening the door to therapies…
Serum from older adults practicing time-restricted eating activates ancient stress-defense pathways and suppresses mTORC1 in cerebral endothelial cells, revealing a circulating shield against vascular…
A 100% false-positive rate in healthy adults reveals critical flaws in the reference genome underpinning clinical DNA interpretation
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European expert consensus declares revascularization offers no added benefit for most HFrEF patients already on four-pillar guideline-directed therapy
The landmark LITMUS study reveals that blood biomarkers and imaging tools each answer different clinical questions in fatty liver disease, charting a credible path…
Landmark multi-omics atlas reveals how immune cell replacement, astrocyte decline, and DNA architecture erosion reshape the brain's memory center between ages 50 and 75
ACC's new consensus pathway gives clinicians a structured playbook for diagnosing, phenotyping, and treating HFpEF with SGLT2 inhibitors and targeted comorbidity management
A 978,000-person analysis reveals medications have masked cardiovascular risk in older adults with obesity — while younger patients remain dangerously unprotected
Landmark longitudinal study identifies 23 metabolites — including 9 novel signals — that diverge decades before clinical heart failure, opening an unprecedented window for…
First human evidence reveals immune cells actively attacking Apolipoprotein B inside coronary plaques, reframing heart disease as an autoimmune battleground