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Serum from older adults practicing time-restricted eating activates ancient stress-defense pathways and suppresses mTORC1 in cerebral endothelial cells, revealing a circulating shield against vascular…
A 100% false-positive rate in healthy adults reveals critical flaws in the reference genome underpinning clinical DNA interpretation
European expert consensus declares revascularization offers no added benefit for most HFrEF patients already on four-pillar guideline-directed therapy
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The landmark LITMUS study reveals that blood biomarkers and imaging tools each answer different clinical questions in fatty liver disease, charting a credible path…
Landmark multi-omics atlas reveals how immune cell replacement, astrocyte decline, and DNA architecture erosion reshape the brain's memory center between ages 50 and 75
ACC's new consensus pathway gives clinicians a structured playbook for diagnosing, phenotyping, and treating HFpEF with SGLT2 inhibitors and targeted comorbidity management
A 978,000-person analysis reveals medications have masked cardiovascular risk in older adults with obesity — while younger patients remain dangerously unprotected
Landmark longitudinal study identifies 23 metabolites — including 9 novel signals — that diverge decades before clinical heart failure, opening an unprecedented window for…
First human evidence reveals immune cells actively attacking Apolipoprotein B inside coronary plaques, reframing heart disease as an autoimmune battleground
First-ever sequential human kidney biopsies with single-cell RNA sequencing reveal SGLT2 inhibitors reprogram tubular metabolism, quell inflammation, and fortify the filtration barrier