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A 160-study meta-regression reveals that sodium restriction prevents one cardiovascular event per 87 older hypertensive adults versus one per 1,334 young normotensives — demanding…
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Advanced diffusion MRI reveals a hidden decade-long window of silent vascular damage — and a landmark chance to intervene before strokes and dementia strike
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New drug classes targeting untouched biological pathways converge with aggressive 2025 AHA/ACC targets to reshape blood pressure management for millions
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A 100% false-positive rate in healthy adults reveals critical flaws in the reference genome underpinning clinical DNA interpretation
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European expert consensus declares revascularization offers no added benefit for most HFrEF patients already on four-pillar guideline-directed therapy
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The landmark LITMUS study reveals that blood biomarkers and imaging tools each answer different clinical questions in fatty liver disease, charting a credible path…
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Landmark multi-omics atlas reveals how immune cell replacement, astrocyte decline, and DNA architecture erosion reshape the brain's memory center between ages 50 and 75
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ACC's new consensus pathway gives clinicians a structured playbook for diagnosing, phenotyping, and treating HFpEF with SGLT2 inhibitors and targeted comorbidity management
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A 978,000-person analysis reveals medications have masked cardiovascular risk in older adults with obesity — while younger patients remain dangerously unprotected
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Landmark longitudinal study identifies 23 metabolites — including 9 novel signals — that diverge decades before clinical heart failure, opening an unprecedented window for…
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First human evidence reveals immune cells actively attacking Apolipoprotein B inside coronary plaques, reframing heart disease as an autoimmune battleground
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First-ever sequential human kidney biopsies with single-cell RNA sequencing reveal SGLT2 inhibitors reprogram tubular metabolism, quell inflammation, and fortify the filtration barrier
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